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The principal cytochrome P450 isoenzyme concerned seems for being CYP2E1, with CYP1A2 and CYP3A4 as more pathways. About 85% of the oral dose seems while in the urine in 24 hours of administration, most since the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity information.Also infor